ABSTRACT
Background and Aims: Purpose of the study was to research the complication rate of acute complications and outcomes of hospitalized patients with COVID-19 and diabetes mellitus Methods: . A retrospective analysis of the 1,500 medical histories of hospitalized patients with a confirmed diagnosis of COVID-19 at the infectious hospitals in Karaganda city, Republic of Kazakhstan. Among patients there were 86 (36.6%) men, 149 (63.4%) women, the median age was 63, (Q1 = 53, Q3 = 71). The complication rate of acute complications of COVID-19 and the outcomes of the disease was conducted. The comparison group consisted of patients without diabetes, n = 1265 patients. Results: The following complications were more common in the presence of diabetes mellitus: acute respiratory distress syndrome in 2.9 times (p < 0.001), acute respiratory failure in 1.8 times (p < 0.001), oxygen insufflation requirement in 1.9 times (p < 0.001). Artificial pulmonary ventilation and the requirement for treatment in the intensive care unit were higher in the group of patients with diabetes mellitus 3.7 and 2.4 times, respectively (p < 0.001). The lethal outcome was 2.1 times higher than in the group of patients without diabetes (p < 0.001). The main causes of the mortality were: acute cardiopulmonary failure-28.2%, pulmonary embolism in 24%, multiple organ failure in 10.9%, infectious-toxic shock in 30.4%, other types of shock in 2.2 %, cerebral edema in 4.3%. Conclusions: The course of Covid-19 on the background of diabetes mellitus is distinguished by a high rate of complications and mortality.